Ebook: Frontiers in Thyroidology: Volume 1

"Frontiers In Thyroidology" assembles the prize lectures, symposia, and papers presented during the Ninth International Thyroid Congress in Sao Paulo, Brazil in September, 1985. This book represents the State-of­ the-Art in thyroid studies with its continuous expansion into the areas of immunology, molecular biology, clinical and environmental medicine. As its name also indicates, the material compiled in this volume defines important questions to be answered in basic and applied aspects of the thyroid. So, this book clearly demonstrates the rewards, excitement, and challenges posed by the thyroid gland. Once again, the thyroid gland, through its unique and important functions and implications in health and disease, has been able to congregate scientists throughout the world to communicate their findings, to share their expertise and experiences, and to strengthen their bonds of friendship and commitment to make a better world through their work. This publication consists of 309 papers in 19 different topics. The prize lectures and symposia review and update our knowledge in basic and clinical aspects of exceptional interest in the thyroid field. "Frontiers in Thyroidology" adds to a series of publications from previous interna­ tional thyroid meetings which includes: "Advances in Thyroid Research", London, 1960; "Current Topics in Thyroid Research", Rome, 1965; "Further Advances in Thyroid Research", Vienna, 1970; "Thyroid Research", Boston, 1975, and "Thyroid Research VIII", Sydney, 1980. We would like to express our gratitude to Mrs. P. Langford and Drs.

---

---

Content:
Front Matter....Pages I-XXXII
Thyrotropin-Releasing Hormone Action in Thyrotropic Cells: Mechanism of Stimulation of Thyroid-Stimulating Hormone Secretion....Pages 1-4
Thyroid Hormones and the Developing Brain....Pages 5-17
Iodine-Sufficient Goiter and Autoimmune Thyroiditis: The Kentucky and Colombian Experience....Pages 19-25
Neonatal Hypothyroid Screening: Nationwide Experience in Japan....Pages 27-35
Iodine Deficiency, the Thyroid, and the Brain....Pages 37-43
An Overview of the Neuroendocrine Control of TSH and PRL, TSH Biosynthesis, Pituitary Deiodinase, and TSH-Producing Tumors....Pages 45-48
The Neuroregulation of TSH and Prolactin Secretion....Pages 49-55
TSH Biosynthesis....Pages 57-64
Role of the Pituitary Iodothyronine 5’Deiodinase Activity in the Negative Feedback by Thyroid Hormone upon TSH Release....Pages 65-70
TSH-Secreting Pituitary Tumors....Pages 71-77
Emerging Concepts in Inherited Disorders of Thyroid Metabolism....Pages 79-81
Hereditable Defects in Thyroid Peroxidase Function....Pages 83-90
Hereditary Goiter with Thyroglobulin Deficiency....Pages 91-95
Thyroid Hormone-Binding Plasma Proteins....Pages 97-101
Inherited Disorders of Thyroid Hormone Action....Pages 103-108
Expectations in the Study on Growth Regulation of Thyroid Epithelial Cells in Vitro....Pages 109-112
Growth Control of Follicular Cells in Vitro....Pages 113-118
Control of Proliferation and of the Expression of Differentiation in Thyroid Cells in Culture....Pages 119-124
Post-Receptor Events in Growth Control....Pages 125-130
Growth Control and Follicular Cell Neoplasia....Pages 131-137
Clinical Problems in Thyroid Disease....Pages 139-142
Transplacental Antibody-Induced Neonatal Syndromes....Pages 143-149
Labeled Antibodies in the Localization and Therapy of Thyroid Carcinoma....Pages 151-160
Amiodarone and the Thyroid....Pages 161-168
Isolation and Characterization of the Gene Encoding the ß-Subunit of Rat Thyrotropin....Pages 169-172
Isolation of a Gene Encoding Human Thyrotropin Beta Subunit....Pages 173-176
Autoradiographical Portrayal of Distribution Patterns of TSH Receptors in Human Thyroid Gland Tissues....Pages 177-180
Bovine Thyrotropin Binding Sites in Nuclei and Nuclear Matrix of Porcine Thyrocytes....Pages 181-186
Flow Cytometric Analysis of TSH Binding to Its Receptors....Pages 187-192
Ganglioside and Phospholipid Content in Normal and Pathological Human Thyroid....Pages 193-198
Characterization of the Optimal Thyrotropin (TSH) Induced Cyclic AMP Accumulation in the Cloned Human Thyroid Cell Line (GEJ)....Pages 199-203
Clinical Experience with a Sensitive Immunoradiometric Assay for Serum Thyrotropin (TSH): Diagnostic and Therapeutic Implications for Hyperthyroid and Thyroid Cancer Patients....Pages 205-209
A Highly Sensitive, Non-Isotopic Assay for Human TSH with Extended Clinical Utility....Pages 211-214
Measurement of Circulating Thyrotropin Concentrations by an Immunochemiluminometric Assay....Pages 215-219
Evaluation of Patients on Thyroxine (T4) Replacement with a Highly Sensitive Commercial TSH Immunoradiometric Assay (TSH-IRMA)....Pages 221-224
Studies of Calmodulin-Like Portion in the TSH Receptor....Pages 225-231
TSH Secretory Regulation: New Evidence that Triiodothyronine (T3) and Thyroxine (T4) Can Inhibit TRH Secretion Both in Vivo and in Vitro....Pages 233-236
Effect of TRH on 5’-Deiodinases in Rat Pituitary Glands....Pages 237-241
Perinatal Pituitary-Thyroid Function at High Altitude....Pages 243-247
Human Fetal Prolactin but not TSH Secretion is Affected by Dopaminergic Stimuli....Pages 249-253
Cholinergic Agents and Inhibitors of Extracellular Calcium Influx Suppress the Secretion of TSH by Human Thyrotropic Adenoma Cells Maintained in Longterm Culture....Pages 255-258
Comparison of a Pituitary TSH-Secreting Micro- Versus Macroadenoma....Pages 259-265
Defective TSH Suppression in a Case of Non-Neoplastic Inappropriate TSH Secretion (ITSHS)....Pages 267-270
Thyrotropin Secretion in Thalassemic Patients during Puberty and Postpuberty....Pages 271-275
Thyroid Function and Prolactin Secretion in Women with Menstrual Disorders and/or Infertility....Pages 277-280
α-Adrenergic Control of TSH Secretion in Man....Pages 281-284
TSH and Thyroidal Responses to Continuous and Intermittent TRH Administration....Pages 285-290
Measurements of Thyrotropin-Releasing Hormone (TRH)-Like Immunoreactivity in Human Blood in Thyroid Diseases....Pages 291-293
Immunoreactive TRH and TRH-OH in Rat Hypophysial Portal Blood....Pages 295-298
Ontogeny of Human Pancreatic Thyrotropin-Releasing Hormone....Pages 299-301
Dopamine and L-Dopa, Precursors of Norepinephrine: Effects on Thyroxine Release....Pages 303-306
Short-Term in Vitro Stimulatory Effect of Glucagon on T4 Secretion in Rat and Human Thyroid....Pages 307-311
Effects of Phorbol Esters on Protein Phosphorylation and Free T3 Release by Mouse Thyroid Lobes....Pages 313-317
Acute in Vitro Stimulatory Effect of Thyrotropin Releasing Hormone (TRH) on T4 Secretion in Rat and Human Thyroid....Pages 319-323
Effect of Calmodulin Inhibitors on Thyroid Hormone Secretion....Pages 325-329
Thyrotropic Activity of Acid Isoelectric Variants of Human Chorionic Gonadotropin from Trophoblastic Tumors....Pages 331-333
Effects of Neuropeptides and TSH on Thyroid Blood Flow and Hormone Secretion....Pages 335-338
Effect of Protein Kinase C Activation on Thyroid Cell Growth and Function....Pages 339-343
Control of Proliferation and Differentiation in Primary Cultures of Calf Thyroid Cells....Pages 345-350
Growth Factor Requirement of Isolated Thyroid Follicles....Pages 351-352
Production of Both Types of Insulin-Like Growth Factors by Primary Cultures of Ovine Thyroid Cells....Pages 353-357
The Effect of Epidermal Growth Factor (EGF) on Thyroid Function in the Sheep and in Isolated Rat Hepatocytes....Pages 359-363
Formation of Intracytoplasmic Microfollicular Lumina in Dispersed Thyroid Cells....Pages 365-367
Different Calcium Requirements for Low Iodine Diet (LID) Induced and Developmental Growth of the Rat Thyroid: Evidence from in Culture Experiments....Pages 369-373
Effects of the Chronic and Acute Treatments of Pig Thyroid Cells with Forskolin on the Cyclic AMP Accumulation, the Phospholipid Turnover, and Iodination....Pages 375-378
Regulatory Networks in the Acute Control of Thyroid Function....Pages 379-384
Stimulation of Thyroid Adenylate Cyclase Activity in Sera of Patients with Nonthyroidal Illness....Pages 385-389
Hormonal Regulation of DNA Polymerase ß Activity in Rat Thyroid Gland....Pages 391-395
Norepinephrine and TSH Stimulation on Iodide Efflux in FRTL-5 Thyroid Cells Involves Metabolites of Arachidonic Acid and is Associated with the Iodination of Thyroglobulin....Pages 397-401
Effect of TSH and Thyroid-Stimulating Antibody (TSAb) on the Desensitization of the Adenylate Cyclase Activity in FRTL-5 Cells....Pages 403-406
Regulation of HLA-DR Gene Expression in Cultured Human Thyroid Cells: A Role for Lectin, Gamma Interferon, and Cyclosporine....Pages 407-410
Thyroid Hormone Structure-Activity Relationships: An Unusual Conformation for 3, 5, 3’-Triiodothyropropionic Acid....Pages 411-415
Chromatographic Properties and Probable Structure of the Urinary Conjugate of an Ethane-1,2-Diol Formed in Vivo from 3,5,3’-Triiodothyronine (T3)....Pages 417-421
Effects of d-Propranolol Treatment on Transport of Thyroid Hormones into Tissue Cells....Pages 423-427
Impaired Release of Hepatic Triiodothyronine (T3) in the Diabetic Low T3 Syndrome....Pages 429-432
Metabolism of rT3 by Isolated Rat Hepatocytes....Pages 433-436
Thyroid Hormone Metabolism in Kidney Epithelial Cells in Continuous Culture....Pages 437-441
Extrathyroidal Conversion of Thyroxine To 3,5,3’-Triiodothyronine in Rats Undergoing Acute Immobilization Stress....Pages 443-447
Effect of Cadmium on Thyroid Hormone Metabolism....Pages 449-454
Preferential Metabolism of T4 to rT3 (T3 Reverse) in Hyperthyroxinemia Induced by L-Thyroxine (L-T4) Treatment of Hypothyroidism in Children and Adolescents....Pages 455-460
NADPH with Cytosol Stimulates Deiodination by Detergent-Solubilized Hepatic Microsomes: Evidence for NADPH-Dependent Cytosolic Non-Glutathione Reductase System....Pages 461-464
The Ionic Microscope Enables the Visualization of Stable Iodine within Follicles of the Human Thyroid Gland....Pages 465-469
Endocytosis of Organified Iodine in the Endostyle of the Amphioxus....Pages 471-475
Human Hepatoma (Hep G2) Cells Secrete a Novel T4-Binding Protein (27 K Protein)....Pages 477-480
Partial Purification of Rat Serum Thyroxine-Binding Globulin....Pages 481-484
Thyroid Function Tests in Subjects with a Genetic Isoelectric Focusing Variant TBG....Pages 485-489
Effect of Long-Chain Fatty Acids on the Binding of T4 and T3 to Human Thyroxine-Binding Globulin (TBG)....Pages 491-494
An Unusual Type of Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Family....Pages 495-498
Peripheral Metabolism of Thyroid Hormones in Congenital Thyroid Hormone Transport Abnormalities: Familial Dysalbuminemic Hyperthyroxinemia and TBG Increase....Pages 499-503
Free T4 Index Results are Non-Specific in Patients with Hypothyroxinemia....Pages 505-508
Measurement of “Free Thyroxine” in Dried Blood Samples on Filter Paper by Radio- and Enzyme-Immunoassay for Monitoring Thyroid Function....Pages 509-512
Effect of Dilution on FT3 and FT4 Concentration in Serum Containing Substances That Interact with Thyroid Hormone-Binding Proteins....Pages 513-518
Evidence for Dual Peripheral 5’Deiodinases (5’D) Regulating Circulating T3 Levels in Man....Pages 519-523
Evidence for Peripheral Autoregulation of Thyroxine Conversion....Pages 525-530
Sites of T4 to T3 Conversion in the Rat....Pages 531-535
Evaluation of Oleic Acid, Arachidonic Acid, and Various Drugs as Competitors for Serum Binding of Thyroxine....Pages 537-541
Alterations in Thyroid Function Parameters Following Administration of Fatty Acids....Pages 543-548
A New Form of X-Chromosome Linked TBG Abnormality with No Demonstrable T4-Binding Activity....Pages 549-550
Normal Cellular Uptake of Thyroxine (T4) from Serum of Patients with Familial Dysalbuminemic Hyperthyroxinemia (FDH) or Elevated Thyroxine-Binding Globulin (TBG): T4 Bound to Albumin is not Preferentially Transferred to Tissue....Pages 551-552
Carrier-Mediated Transport of Thyroid Hormone (TH) into Rat Hepatocytes is Rate Limiting in Total Cellular Uptake and Metabolism....Pages 553-556
Enhanced Rate of Cellular Uptake of Thyroxine (T4) from Sera of Subjects with Familial Dysalbuminemic Hyperthyroxinemia (FDH)....Pages 557-561
Elevation of Sex Hormone Binding Globulin (SHBG) Levels in Some Sera with Inherited Increase in Thyroxine Binding Globulin (TBG)....Pages 563-567
Identification and Regulation of Thyroperoxidase: Use of Specific Antiserum....Pages 569-573
Irreversible Inactivation of Lactoperoxidase by Excess Hydrogen Peroxide Involving Cleavage of the Catalytic Heme Moiety....Pages 575-579
Residual Capacity for Iodide Organification in Human Thyroid Slices Provoked by Hydrogen Peroxide....Pages 581-586
T3 and rT3 Generation from Exogenous and Endogenous T4 in Perfused Dog Thyroids....Pages 587-590
Effects of Synthetic Iodolipids on Thyroid Function “In Vitro”: Possible Role in Thyroid Regulation....Pages 591-593
Formation of Diiodotyrosine (DIT) by Ether-Link Cleavage of T4 in Rat Liver Homogenate as Measured by DIT Radioimmunoassay....Pages 595-599
Is Iodide Required for Peroxidase-Catalyzed Coupling in Thyroglobulin?....Pages 601-605
Inhibition of Thyroid Peroxidase (TPO) and Lactoperoxidase (LPO) by Goitrin and Ricinine....Pages 607-612
Selective Inhibition by Monoamine Oxidase (MAO) Inhibitors of the Iodotyrosine Formation Induced by MAO Substrates in Bovine Thyroid Tissue....Pages 613-617
Thyroid Function in Fasting Rats....Pages 619-625
Insulin Deficiency Impairs Thyroid Peroxidase Activity: A Study in Experimental Diabetes Mellitus....Pages 627-630
On the Mechanism of Irreversible Brain Damage Caused by Perinatal Thyroid Hormone Deficiency....Pages 631-635
Regulation of 19,000 Mr Soluble Protein and High Mobility Group Protein (HMG 14) Phosphorylation by Triiodothyronine (T3) in Primary Astrocytic Cultures....Pages 637-640
Regulation by n-Butyrate of Thyroid Hormone Receptor Levels in Cultured Cells of Glial Origin....Pages 641-645
Inhibitory Effect of Thyroid Hormone on Protein Synthesis by Fetal Rat Neurons in Primary Culture....Pages 647-650
Effects of T3 and Dexamethasone on Proliferation and Enzyme Activities of Glial Cells in Culture....Pages 651-654
Healing Effects of Iodine and Thyroid Hormone on Experimental Rickets....Pages 655-660
Thyroid Hormone Stimulates Red Blood Cell Ca++-Dependent ATPase Activity Through a “Non-Hormonal” Effect....Pages 661-666
Induction of Metamorphosis and Thyroid Function in the Larval Lamprey....Pages 667-670
Differential Effect of Hypothyroidism on the Dendritic Density of Pyramidal Neurons of the Cerebral Cortex....Pages 671-676
Prostacyclin (PGI2) Production in Hyperthyroid Rats and Patients with Graves’ Disease....Pages 677-680
Regulation of Rat Liver Glycerophospholipid Fatty Acid Composition in Hypo- and Hyperthyroidism....Pages 681-684
Effect of Thyroxine Replacement Therapy on Serum Thyrotropin....Pages 685-688
Thyroxine-Induced Molting and Gonadal Functions of Laying Hens....Pages 689-692
Glucagon Causes Disappearance of a T3 and Carbohydrate-Inducible Rat Hepatic mRNA (mRNAS14): Unexpected Circadian Dependency of Response....Pages 693-696
Suppression of Triiodothyronine-Induced Growth Hormone Gene Expression by Insulin-Like Growth Factor-I in Thyroidectomized Rat Pituitary Cells....Pages 697-700
Hypothyroidism Inhibits the Rapid Response of mRNA-S14 to Carbohydrate Feeding....Pages 701-704
Thyroid Hormone Stimulates Alkaline Phosphatase Activity in Cultured Osteoblastic Cells with T3 Nuclear Receptors....Pages 705-708
Studies on the Effects of Thyroid Hormones and their Metabolites on Human Red Cell Acetylcholine Esterase....Pages 709-712
Evidence for Nuclear T3 Receptors in Neonatal Cerebral Astrocytes....Pages 713-716
Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT)....Pages 717-720
Induction of Liver Mitochondrial α-Glycerophosphate Dehydrogenase (α-GPD) by Glucocorticoid Deficit: Role of the Nuclear T3-Receptor (nT3-R)....Pages 721-725
Ontogeny of Nuclear T3 Receptor in Primary Cultured Astrocytes....Pages 727-729
Purification and Characterization of T3-Receptor from Beef Liver Plasma Membrane....Pages 731-735
Effect of the Thyroid Status on the Properties of the β-Receptors of Adipocytes as Related to Lipolysis....Pages 737-740
Receptor Induction by Thyroid Hormones in Tadpole Erythrocytes in Vivo and in Vitro....Pages 741-743
Putative Nuclear Triiodothyronine Receptors in Tadpole Liver during Metamorphic Climax....Pages 745-749
Activity of T3–Responsive α–Glycerophosphate Dehydrogenase (α–GPD) and the Characteristics of Nuclear T3–Binding in the Male and Female Rat....Pages 751-754
Role of T4 in the Modulation of Pituitary T3 Nuclear Receptors (T3nR) in Hypothyroid Rats....Pages 755-758
Human Nuclear Thyroid Hormone Receptors....Pages 759-762
Ontogeny of Thyroid during Embryogenesis: Evidence of Two Thyroxine Binding Sites....Pages 763-766
Insulin, Glucose, and Glucagon are Potential Modulators of Thyroid Hormone Action Through Brown Adipose Tissue 5′-Deiodinase in Rats....Pages 767-771
Effect of Thyroid Hormones, Food Deprivation, and Cold Exposure on Thyroid T4 Outer Ring Monodeiodinating Activity (5’MDI) in Mice....Pages 773-777
3,3′,5′-Triiodothyronine (rT3) Inhibits Iodothyronine-5′-Deiodinating Activity Induced by Equimolar Concentration of 3,5,3′-Triiodothyronine (T3) in Cultured Fetal Liver of Mouse....Pages 779-782
Design of Active Site-Directed Iodothyronine Deiodinase Ligands Using TBPA as a Binding Site Model....Pages 783-788
Generated Dihydrolipoamide and Cytosolic Components Stimulate Hepatic Microsomal Thyroxine 5’-Deiodination: Similar Effects of Cytosolic Components on Other Sulfhydryl Compounds....Pages 789-792
Characteristics of T4 Inner Ring Deiodinase in the Liver, Kidney, and Cerebral Cortex of Rat: Two Kinds of Isoenzymes....Pages 793-797
Inhibition of T4 5’-Deiodinase in Human Placental Cells by Cyclic-AMP, Butyrate, and Calcium....Pages 799-802

---

Content:
Front Matter....Pages I-XXXII
Thyrotropin-Releasing Hormone Action in Thyrotropic Cells: Mechanism of Stimulation of Thyroid-Stimulating Hormone Secretion....Pages 1-4
Thyroid Hormones and the Developing Brain....Pages 5-17
Iodine-Sufficient Goiter and Autoimmune Thyroiditis: The Kentucky and Colombian Experience....Pages 19-25
Neonatal Hypothyroid Screening: Nationwide Experience in Japan....Pages 27-35
Iodine Deficiency, the Thyroid, and the Brain....Pages 37-43
An Overview of the Neuroendocrine Control of TSH and PRL, TSH Biosynthesis, Pituitary Deiodinase, and TSH-Producing Tumors....Pages 45-48
The Neuroregulation of TSH and Prolactin Secretion....Pages 49-55
TSH Biosynthesis....Pages 57-64
Role of the Pituitary Iodothyronine 5’Deiodinase Activity in the Negative Feedback by Thyroid Hormone upon TSH Release....Pages 65-70
TSH-Secreting Pituitary Tumors....Pages 71-77
Emerging Concepts in Inherited Disorders of Thyroid Metabolism....Pages 79-81
Hereditable Defects in Thyroid Peroxidase Function....Pages 83-90
Hereditary Goiter with Thyroglobulin Deficiency....Pages 91-95
Thyroid Hormone-Binding Plasma Proteins....Pages 97-101
Inherited Disorders of Thyroid Hormone Action....Pages 103-108
Expectations in the Study on Growth Regulation of Thyroid Epithelial Cells in Vitro....Pages 109-112
Growth Control of Follicular Cells in Vitro....Pages 113-118
Control of Proliferation and of the Expression of Differentiation in Thyroid Cells in Culture....Pages 119-124
Post-Receptor Events in Growth Control....Pages 125-130
Growth Control and Follicular Cell Neoplasia....Pages 131-137
Clinical Problems in Thyroid Disease....Pages 139-142
Transplacental Antibody-Induced Neonatal Syndromes....Pages 143-149
Labeled Antibodies in the Localization and Therapy of Thyroid Carcinoma....Pages 151-160
Amiodarone and the Thyroid....Pages 161-168
Isolation and Characterization of the Gene Encoding the ß-Subunit of Rat Thyrotropin....Pages 169-172
Isolation of a Gene Encoding Human Thyrotropin Beta Subunit....Pages 173-176
Autoradiographical Portrayal of Distribution Patterns of TSH Receptors in Human Thyroid Gland Tissues....Pages 177-180
Bovine Thyrotropin Binding Sites in Nuclei and Nuclear Matrix of Porcine Thyrocytes....Pages 181-186
Flow Cytometric Analysis of TSH Binding to Its Receptors....Pages 187-192
Ganglioside and Phospholipid Content in Normal and Pathological Human Thyroid....Pages 193-198
Characterization of the Optimal Thyrotropin (TSH) Induced Cyclic AMP Accumulation in the Cloned Human Thyroid Cell Line (GEJ)....Pages 199-203
Clinical Experience with a Sensitive Immunoradiometric Assay for Serum Thyrotropin (TSH): Diagnostic and Therapeutic Implications for Hyperthyroid and Thyroid Cancer Patients....Pages 205-209
A Highly Sensitive, Non-Isotopic Assay for Human TSH with Extended Clinical Utility....Pages 211-214
Measurement of Circulating Thyrotropin Concentrations by an Immunochemiluminometric Assay....Pages 215-219
Evaluation of Patients on Thyroxine (T4) Replacement with a Highly Sensitive Commercial TSH Immunoradiometric Assay (TSH-IRMA)....Pages 221-224
Studies of Calmodulin-Like Portion in the TSH Receptor....Pages 225-231
TSH Secretory Regulation: New Evidence that Triiodothyronine (T3) and Thyroxine (T4) Can Inhibit TRH Secretion Both in Vivo and in Vitro....Pages 233-236
Effect of TRH on 5’-Deiodinases in Rat Pituitary Glands....Pages 237-241
Perinatal Pituitary-Thyroid Function at High Altitude....Pages 243-247
Human Fetal Prolactin but not TSH Secretion is Affected by Dopaminergic Stimuli....Pages 249-253
Cholinergic Agents and Inhibitors of Extracellular Calcium Influx Suppress the Secretion of TSH by Human Thyrotropic Adenoma Cells Maintained in Longterm Culture....Pages 255-258
Comparison of a Pituitary TSH-Secreting Micro- Versus Macroadenoma....Pages 259-265
Defective TSH Suppression in a Case of Non-Neoplastic Inappropriate TSH Secretion (ITSHS)....Pages 267-270
Thyrotropin Secretion in Thalassemic Patients during Puberty and Postpuberty....Pages 271-275
Thyroid Function and Prolactin Secretion in Women with Menstrual Disorders and/or Infertility....Pages 277-280
α-Adrenergic Control of TSH Secretion in Man....Pages 281-284
TSH and Thyroidal Responses to Continuous and Intermittent TRH Administration....Pages 285-290
Measurements of Thyrotropin-Releasing Hormone (TRH)-Like Immunoreactivity in Human Blood in Thyroid Diseases....Pages 291-293
Immunoreactive TRH and TRH-OH in Rat Hypophysial Portal Blood....Pages 295-298
Ontogeny of Human Pancreatic Thyrotropin-Releasing Hormone....Pages 299-301
Dopamine and L-Dopa, Precursors of Norepinephrine: Effects on Thyroxine Release....Pages 303-306
Short-Term in Vitro Stimulatory Effect of Glucagon on T4 Secretion in Rat and Human Thyroid....Pages 307-311
Effects of Phorbol Esters on Protein Phosphorylation and Free T3 Release by Mouse Thyroid Lobes....Pages 313-317
Acute in Vitro Stimulatory Effect of Thyrotropin Releasing Hormone (TRH) on T4 Secretion in Rat and Human Thyroid....Pages 319-323
Effect of Calmodulin Inhibitors on Thyroid Hormone Secretion....Pages 325-329
Thyrotropic Activity of Acid Isoelectric Variants of Human Chorionic Gonadotropin from Trophoblastic Tumors....Pages 331-333
Effects of Neuropeptides and TSH on Thyroid Blood Flow and Hormone Secretion....Pages 335-338
Effect of Protein Kinase C Activation on Thyroid Cell Growth and Function....Pages 339-343
Control of Proliferation and Differentiation in Primary Cultures of Calf Thyroid Cells....Pages 345-350
Growth Factor Requirement of Isolated Thyroid Follicles....Pages 351-352
Production of Both Types of Insulin-Like Growth Factors by Primary Cultures of Ovine Thyroid Cells....Pages 353-357
The Effect of Epidermal Growth Factor (EGF) on Thyroid Function in the Sheep and in Isolated Rat Hepatocytes....Pages 359-363
Formation of Intracytoplasmic Microfollicular Lumina in Dispersed Thyroid Cells....Pages 365-367
Different Calcium Requirements for Low Iodine Diet (LID) Induced and Developmental Growth of the Rat Thyroid: Evidence from in Culture Experiments....Pages 369-373
Effects of the Chronic and Acute Treatments of Pig Thyroid Cells with Forskolin on the Cyclic AMP Accumulation, the Phospholipid Turnover, and Iodination....Pages 375-378
Regulatory Networks in the Acute Control of Thyroid Function....Pages 379-384
Stimulation of Thyroid Adenylate Cyclase Activity in Sera of Patients with Nonthyroidal Illness....Pages 385-389
Hormonal Regulation of DNA Polymerase ß Activity in Rat Thyroid Gland....Pages 391-395
Norepinephrine and TSH Stimulation on Iodide Efflux in FRTL-5 Thyroid Cells Involves Metabolites of Arachidonic Acid and is Associated with the Iodination of Thyroglobulin....Pages 397-401
Effect of TSH and Thyroid-Stimulating Antibody (TSAb) on the Desensitization of the Adenylate Cyclase Activity in FRTL-5 Cells....Pages 403-406
Regulation of HLA-DR Gene Expression in Cultured Human Thyroid Cells: A Role for Lectin, Gamma Interferon, and Cyclosporine....Pages 407-410
Thyroid Hormone Structure-Activity Relationships: An Unusual Conformation for 3, 5, 3’-Triiodothyropropionic Acid....Pages 411-415
Chromatographic Properties and Probable Structure of the Urinary Conjugate of an Ethane-1,2-Diol Formed in Vivo from 3,5,3’-Triiodothyronine (T3)....Pages 417-421
Effects of d-Propranolol Treatment on Transport of Thyroid Hormones into Tissue Cells....Pages 423-427
Impaired Release of Hepatic Triiodothyronine (T3) in the Diabetic Low T3 Syndrome....Pages 429-432
Metabolism of rT3 by Isolated Rat Hepatocytes....Pages 433-436
Thyroid Hormone Metabolism in Kidney Epithelial Cells in Continuous Culture....Pages 437-441
Extrathyroidal Conversion of Thyroxine To 3,5,3’-Triiodothyronine in Rats Undergoing Acute Immobilization Stress....Pages 443-447
Effect of Cadmium on Thyroid Hormone Metabolism....Pages 449-454
Preferential Metabolism of T4 to rT3 (T3 Reverse) in Hyperthyroxinemia Induced by L-Thyroxine (L-T4) Treatment of Hypothyroidism in Children and Adolescents....Pages 455-460
NADPH with Cytosol Stimulates Deiodination by Detergent-Solubilized Hepatic Microsomes: Evidence for NADPH-Dependent Cytosolic Non-Glutathione Reductase System....Pages 461-464
The Ionic Microscope Enables the Visualization of Stable Iodine within Follicles of the Human Thyroid Gland....Pages 465-469
Endocytosis of Organified Iodine in the Endostyle of the Amphioxus....Pages 471-475
Human Hepatoma (Hep G2) Cells Secrete a Novel T4-Binding Protein (27 K Protein)....Pages 477-480
Partial Purification of Rat Serum Thyroxine-Binding Globulin....Pages 481-484
Thyroid Function Tests in Subjects with a Genetic Isoelectric Focusing Variant TBG....Pages 485-489
Effect of Long-Chain Fatty Acids on the Binding of T4 and T3 to Human Thyroxine-Binding Globulin (TBG)....Pages 491-494
An Unusual Type of Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Family....Pages 495-498
Peripheral Metabolism of Thyroid Hormones in Congenital Thyroid Hormone Transport Abnormalities: Familial Dysalbuminemic Hyperthyroxinemia and TBG Increase....Pages 499-503
Free T4 Index Results are Non-Specific in Patients with Hypothyroxinemia....Pages 505-508
Measurement of “Free Thyroxine” in Dried Blood Samples on Filter Paper by Radio- and Enzyme-Immunoassay for Monitoring Thyroid Function....Pages 509-512
Effect of Dilution on FT3 and FT4 Concentration in Serum Containing Substances That Interact with Thyroid Hormone-Binding Proteins....Pages 513-518
Evidence for Dual Peripheral 5’Deiodinases (5’D) Regulating Circulating T3 Levels in Man....Pages 519-523
Evidence for Peripheral Autoregulation of Thyroxine Conversion....Pages 525-530
Sites of T4 to T3 Conversion in the Rat....Pages 531-535
Evaluation of Oleic Acid, Arachidonic Acid, and Various Drugs as Competitors for Serum Binding of Thyroxine....Pages 537-541
Alterations in Thyroid Function Parameters Following Administration of Fatty Acids....Pages 543-548
A New Form of X-Chromosome Linked TBG Abnormality with No Demonstrable T4-Binding Activity....Pages 549-550
Normal Cellular Uptake of Thyroxine (T4) from Serum of Patients with Familial Dysalbuminemic Hyperthyroxinemia (FDH) or Elevated Thyroxine-Binding Globulin (TBG): T4 Bound to Albumin is not Preferentially Transferred to Tissue....Pages 551-552
Carrier-Mediated Transport of Thyroid Hormone (TH) into Rat Hepatocytes is Rate Limiting in Total Cellular Uptake and Metabolism....Pages 553-556
Enhanced Rate of Cellular Uptake of Thyroxine (T4) from Sera of Subjects with Familial Dysalbuminemic Hyperthyroxinemia (FDH)....Pages 557-561
Elevation of Sex Hormone Binding Globulin (SHBG) Levels in Some Sera with Inherited Increase in Thyroxine Binding Globulin (TBG)....Pages 563-567
Identification and Regulation of Thyroperoxidase: Use of Specific Antiserum....Pages 569-573
Irreversible Inactivation of Lactoperoxidase by Excess Hydrogen Peroxide Involving Cleavage of the Catalytic Heme Moiety....Pages 575-579
Residual Capacity for Iodide Organification in Human Thyroid Slices Provoked by Hydrogen Peroxide....Pages 581-586
T3 and rT3 Generation from Exogenous and Endogenous T4 in Perfused Dog Thyroids....Pages 587-590
Effects of Synthetic Iodolipids on Thyroid Function “In Vitro”: Possible Role in Thyroid Regulation....Pages 591-593
Formation of Diiodotyrosine (DIT) by Ether-Link Cleavage of T4 in Rat Liver Homogenate as Measured by DIT Radioimmunoassay....Pages 595-599
Is Iodide Required for Peroxidase-Catalyzed Coupling in Thyroglobulin?....Pages 601-605
Inhibition of Thyroid Peroxidase (TPO) and Lactoperoxidase (LPO) by Goitrin and Ricinine....Pages 607-612
Selective Inhibition by Monoamine Oxidase (MAO) Inhibitors of the Iodotyrosine Formation Induced by MAO Substrates in Bovine Thyroid Tissue....Pages 613-617
Thyroid Function in Fasting Rats....Pages 619-625
Insulin Deficiency Impairs Thyroid Peroxidase Activity: A Study in Experimental Diabetes Mellitus....Pages 627-630
On the Mechanism of Irreversible Brain Damage Caused by Perinatal Thyroid Hormone Deficiency....Pages 631-635
Regulation of 19,000 Mr Soluble Protein and High Mobility Group Protein (HMG 14) Phosphorylation by Triiodothyronine (T3) in Primary Astrocytic Cultures....Pages 637-640
Regulation by n-Butyrate of Thyroid Hormone Receptor Levels in Cultured Cells of Glial Origin....Pages 641-645
Inhibitory Effect of Thyroid Hormone on Protein Synthesis by Fetal Rat Neurons in Primary Culture....Pages 647-650
Effects of T3 and Dexamethasone on Proliferation and Enzyme Activities of Glial Cells in Culture....Pages 651-654
Healing Effects of Iodine and Thyroid Hormone on Experimental Rickets....Pages 655-660
Thyroid Hormone Stimulates Red Blood Cell Ca++-Dependent ATPase Activity Through a “Non-Hormonal” Effect....Pages 661-666
Induction of Metamorphosis and Thyroid Function in the Larval Lamprey....Pages 667-670
Differential Effect of Hypothyroidism on the Dendritic Density of Pyramidal Neurons of the Cerebral Cortex....Pages 671-676
Prostacyclin (PGI2) Production in Hyperthyroid Rats and Patients with Graves’ Disease....Pages 677-680
Regulation of Rat Liver Glycerophospholipid Fatty Acid Composition in Hypo- and Hyperthyroidism....Pages 681-684
Effect of Thyroxine Replacement Therapy on Serum Thyrotropin....Pages 685-688
Thyroxine-Induced Molting and Gonadal Functions of Laying Hens....Pages 689-692
Glucagon Causes Disappearance of a T3 and Carbohydrate-Inducible Rat Hepatic mRNA (mRNAS14): Unexpected Circadian Dependency of Response....Pages 693-696
Suppression of Triiodothyronine-Induced Growth Hormone Gene Expression by Insulin-Like Growth Factor-I in Thyroidectomized Rat Pituitary Cells....Pages 697-700
Hypothyroidism Inhibits the Rapid Response of mRNA-S14 to Carbohydrate Feeding....Pages 701-704
Thyroid Hormone Stimulates Alkaline Phosphatase Activity in Cultured Osteoblastic Cells with T3 Nuclear Receptors....Pages 705-708
Studies on the Effects of Thyroid Hormones and their Metabolites on Human Red Cell Acetylcholine Esterase....Pages 709-712
Evidence for Nuclear T3 Receptors in Neonatal Cerebral Astrocytes....Pages 713-716
Direct Thyroid Hormone Stimulation of Mitochondrial Oxidative Phosphorylation: The Role of Adenine Nucleotide Translocase (AdNT)....Pages 717-720
Induction of Liver Mitochondrial α-Glycerophosphate Dehydrogenase (α-GPD) by Glucocorticoid Deficit: Role of the Nuclear T3-Receptor (nT3-R)....Pages 721-725
Ontogeny of Nuclear T3 Receptor in Primary Cultured Astrocytes....Pages 727-729
Purification and Characterization of T3-Receptor from Beef Liver Plasma Membrane....Pages 731-735
Effect of the Thyroid Status on the Properties of the β-Receptors of Adipocytes as Related to Lipolysis....Pages 737-740
Receptor Induction by Thyroid Hormones in Tadpole Erythrocytes in Vivo and in Vitro....Pages 741-743
Putative Nuclear Triiodothyronine Receptors in Tadpole Liver during Metamorphic Climax....Pages 745-749
Activity of T3–Responsive α–Glycerophosphate Dehydrogenase (α–GPD) and the Characteristics of Nuclear T3–Binding in the Male and Female Rat....Pages 751-754
Role of T4 in the Modulation of Pituitary T3 Nuclear Receptors (T3nR) in Hypothyroid Rats....Pages 755-758
Human Nuclear Thyroid Hormone Receptors....Pages 759-762
Ontogeny of Thyroid during Embryogenesis: Evidence of Two Thyroxine Binding Sites....Pages 763-766
Insulin, Glucose, and Glucagon are Potential Modulators of Thyroid Hormone Action Through Brown Adipose Tissue 5′-Deiodinase in Rats....Pages 767-771
Effect of Thyroid Hormones, Food Deprivation, and Cold Exposure on Thyroid T4 Outer Ring Monodeiodinating Activity (5’MDI) in Mice....Pages 773-777
3,3′,5′-Triiodothyronine (rT3) Inhibits Iodothyronine-5′-Deiodinating Activity Induced by Equimolar Concentration of 3,5,3′-Triiodothyronine (T3) in Cultured Fetal Liver of Mouse....Pages 779-782
Design of Active Site-Directed Iodothyronine Deiodinase Ligands Using TBPA as a Binding Site Model....Pages 783-788
Generated Dihydrolipoamide and Cytosolic Components Stimulate Hepatic Microsomal Thyroxine 5’-Deiodination: Similar Effects of Cytosolic Components on Other Sulfhydryl Compounds....Pages 789-792
Characteristics of T4 Inner Ring Deiodinase in the Liver, Kidney, and Cerebral Cortex of Rat: Two Kinds of Isoenzymes....Pages 793-797
Inhibition of T4 5’-Deiodinase in Human Placental Cells by Cyclic-AMP, Butyrate, and Calcium....Pages 799-802
....