Ebook: Human in Vitro Fertilization and Embryo Transfer

The births of more than 100 apparently normal infants at term following pregnancies initiated by in vitro fertilization and embryo transfer testifies to the successful clinical application of insights obtained from studies in reproductive biology over the last 20 years. In women, these studies have included: 1) characterization of the changes in blood hormone profiles throughout ovulatory menstrual cycles; 2) documentation of the hormonal composition of antral fluid in developing and degenerating preovulatory follicles; 3) correlation of these observations with the state of oocyte maturation and the fertilizability of the oocyte; 4) application of pharmacologic agents for perturbing the normal hormone profiles to regulate the number of preovulatory follicles developing and the time of ovulation; and 5) development of non-invasi ve methods for monitoring follicular development. Optimizing methods for maturing and fertilizing eggs, for moni toring normal development in vi tro, and for transferring and achieving implantation of embryos are continuing concerns of physicians and scientists responsible for extant programs. In addition, all serious students of reproductive biology should critically examine every facet of the processes which must concatenate to assure birth of normal infants following pregnancies achieved by these methods. However, the literature which contains the informational substrate is dispersed widely in a plethora of journals not always readily accessible. Bringing the essentials together facilitates both rapid retrieval of data and access to relevant literature.

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Content:
Front Matter....Pages i-xiv
Historical Background and Essentials for a Program in In Vitro Fertilization and Embryo Transfer....Pages 1-9
Legal Issues Raised by In Vitro Fertilization and Embryo Transfer....Pages 11-36
Patient Screening and Selection....Pages 37-46
Hypothalamic Control of the Menstrual Cycle....Pages 47-57
Maturation of the Follicular Microenvironment....Pages 59-79
Enhanced Follicular Development with Clomiphene Citrate and Human Chorionic Gonadotropin....Pages 81-98
Human Menopausal Gonadotropins for Follicular Recruitment in In Vitro Fertilization and Embryo Transfer....Pages 99-117
Monitoring Follicular Development with Ultrasound....Pages 119-132
Monitoring Follicular Development with Estrogens....Pages 133-148
Laparoscopic Follicular Aspiration....Pages 149-169
Sperm Capacitation....Pages 171-211
Oogenesis, Fertilization and Early Development....Pages 213-273
Laboratory Details in an In Vitro Fertilization and Embryo Transfer Program....Pages 275-296
Fertility Potential Evaluation with the Zona-Free Hamster Egg Bioassay....Pages 297-326
Techniques of Embryo Transfer....Pages 327-340
Implantation....Pages 341-364
Pregnancy Management Following In Vitro Fertilization and Embryo Transfer....Pages 365-373
The Clinical Coordinator in an In Vitro Fertilization and Embryo Transfer Program....Pages 375-382
Data Management in an In Vitro Fertilization and Embryo Transfer Program....Pages 383-401
Ethical Considerations in In Vitro Fertilization and Embryo Transfer....Pages 403-423
Back Matter....Pages 425-440

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Content:
Front Matter....Pages i-xiv
Historical Background and Essentials for a Program in In Vitro Fertilization and Embryo Transfer....Pages 1-9
Legal Issues Raised by In Vitro Fertilization and Embryo Transfer....Pages 11-36
Patient Screening and Selection....Pages 37-46
Hypothalamic Control of the Menstrual Cycle....Pages 47-57
Maturation of the Follicular Microenvironment....Pages 59-79
Enhanced Follicular Development with Clomiphene Citrate and Human Chorionic Gonadotropin....Pages 81-98
Human Menopausal Gonadotropins for Follicular Recruitment in In Vitro Fertilization and Embryo Transfer....Pages 99-117
Monitoring Follicular Development with Ultrasound....Pages 119-132
Monitoring Follicular Development with Estrogens....Pages 133-148
Laparoscopic Follicular Aspiration....Pages 149-169
Sperm Capacitation....Pages 171-211
Oogenesis, Fertilization and Early Development....Pages 213-273
Laboratory Details in an In Vitro Fertilization and Embryo Transfer Program....Pages 275-296
Fertility Potential Evaluation with the Zona-Free Hamster Egg Bioassay....Pages 297-326
Techniques of Embryo Transfer....Pages 327-340
Implantation....Pages 341-364
Pregnancy Management Following In Vitro Fertilization and Embryo Transfer....Pages 365-373
The Clinical Coordinator in an In Vitro Fertilization and Embryo Transfer Program....Pages 375-382
Data Management in an In Vitro Fertilization and Embryo Transfer Program....Pages 383-401
Ethical Considerations in In Vitro Fertilization and Embryo Transfer....Pages 403-423
Back Matter....Pages 425-440
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