Ebook: Handbook of Neurochemistry: Volume 6: Receptors in the Nervous System
- Tags: Neurosciences
- Year: 1984
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
A major advance in the biological sciences in the past decade has been the biochemical identification of cell membrane receptors. The existence of re ceptor substances on the surface of cells that recognize and bind to extracellular molecules was proposed at the beginning of the century by the pharmacologist and immunologist Paul Ehrlich and the physiologist J. N. Langley. Since then, receptors have been found to play an important role in numerous physiological and pathological processes. Over the years many attempts have been made to physically isolate and chemically characterize receptors, but because of the receptors' extremely low concentration and membrane localization, these ef forts have met with limited success. Yet, despite the failure to characterize receptor substances, the concept of the presence of such molecules has had considerable heuristic value. Using pharmacological, physiological, and im munologic approaches, researchers have identified several specific receptors, e. g. , a-and ~-adrenergic, nicotinic and muscarinic cholinergic, and histami nergic. With the characterization of various types of receptors on cell mem branes, many drugs were developed that proved to be experimentally and ther apeutically useful. It was only in the early 1970s that methods for the specific measurement, chemical characterization, and physical isolation of cell membrane receptors were developed. These advances were made possible by the availability of ligands with high specific radioactivity that retained their biological activity and of experimental procedures that differentiated between specific and non specific binding of ligands.
Content:
Front Matter....Pages i-xxv
Mammalian Central Adenosine Receptors....Pages 1-26
α-Adrenergic Receptors....Pages 27-38
ß-Adrenergic Receptors....Pages 39-50
Norepinephrine....Pages 51-69
Dopamine....Pages 71-106
Central Serotonin Receptors....Pages 107-143
Histamine and Its Receptors in the Nervous System....Pages 145-211
GABA Receptors....Pages 213-237
Excitatory Amino Acid Receptors....Pages 239-259
Benzodiazepine Receptors....Pages 261-306
Recognition Sites for Antidepressant Drugs....Pages 307-330
Opiate Receptors....Pages 331-352
Peptide Receptors....Pages 353-378
Cholinergic Systems and Cholinergic Pathology....Pages 379-410
Neurotransmitter Uptake....Pages 411-429
Release of Catecholamines, Serotonin, and Acetylcholine from Isolated Brain Tissue....Pages 431-462
Release of Putative Transmitter Amino Acids....Pages 463-509
Transmitter Specificity in Neurons....Pages 511-526
Phospholipid Methylation....Pages 527-539
Protein Phosphorylation....Pages 541-574
Heterogeneity of Benzodiazepine Receptors....Pages 575-593
Modulation of Catecholaminergic Receptors During Development and Aging....Pages 595-627
Receptor Regulation....Pages 629-638
Receptor Adaptation to Psychotropic Drugs....Pages 639-660
Back Matter....Pages 661-668
Content:
Front Matter....Pages i-xxv
Mammalian Central Adenosine Receptors....Pages 1-26
α-Adrenergic Receptors....Pages 27-38
ß-Adrenergic Receptors....Pages 39-50
Norepinephrine....Pages 51-69
Dopamine....Pages 71-106
Central Serotonin Receptors....Pages 107-143
Histamine and Its Receptors in the Nervous System....Pages 145-211
GABA Receptors....Pages 213-237
Excitatory Amino Acid Receptors....Pages 239-259
Benzodiazepine Receptors....Pages 261-306
Recognition Sites for Antidepressant Drugs....Pages 307-330
Opiate Receptors....Pages 331-352
Peptide Receptors....Pages 353-378
Cholinergic Systems and Cholinergic Pathology....Pages 379-410
Neurotransmitter Uptake....Pages 411-429
Release of Catecholamines, Serotonin, and Acetylcholine from Isolated Brain Tissue....Pages 431-462
Release of Putative Transmitter Amino Acids....Pages 463-509
Transmitter Specificity in Neurons....Pages 511-526
Phospholipid Methylation....Pages 527-539
Protein Phosphorylation....Pages 541-574
Heterogeneity of Benzodiazepine Receptors....Pages 575-593
Modulation of Catecholaminergic Receptors During Development and Aging....Pages 595-627
Receptor Regulation....Pages 629-638
Receptor Adaptation to Psychotropic Drugs....Pages 639-660
Back Matter....Pages 661-668
....