Ebook: Obesity, Inflammation and Cancer

In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion.

This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer.

Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.

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In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion.

Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.

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In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion.

Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.

Content:
Front Matter....Pages i-xiii
Obesity, Inflammation, and Insulin Resistance....Pages 1-23
Inflammasomes and Obesity....Pages 25-60
Uncoupling Obesity from Cancer: Bromodomain Co-regulators That Control Inflammatory Networks....Pages 61-81
Adipose Tissue Macrophages in Obesity, Inflammation, and Cancer....Pages 83-98
Dietary Fats as Mediators of Obesity, Inflammation, and Colon Cancer....Pages 99-132
Inflammation, Obesity, Barrett’s Esophagus, and Esophageal Adenocarcinoma....Pages 133-145
Inflammation, Obesity, and Colon Cancer....Pages 147-180
Obesity, Inflammation, and Breast Cancer....Pages 181-217
Obesity, Inflammation, Nonalcoholic Fatty Liver Disease, and Hepatocellular Carcinoma....Pages 219-234
Obesity, Inflammation, and Prostate Cancer....Pages 235-256
Pharmacologic Interventions with NSAIDs....Pages 257-303
Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspective....Pages 305-339
Natural Products as Anti-inflammatory Agents....Pages 341-361
Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms....Pages 363-379
Vascular Targeting of Adipose Tissue....Pages 381-400
Anti-inflammatory Effects of Exercise....Pages 401-424
Back Matter....Pages 425-433

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In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion.

Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.

Content:
Front Matter....Pages i-xiii
Obesity, Inflammation, and Insulin Resistance....Pages 1-23
Inflammasomes and Obesity....Pages 25-60
Uncoupling Obesity from Cancer: Bromodomain Co-regulators That Control Inflammatory Networks....Pages 61-81
Adipose Tissue Macrophages in Obesity, Inflammation, and Cancer....Pages 83-98
Dietary Fats as Mediators of Obesity, Inflammation, and Colon Cancer....Pages 99-132
Inflammation, Obesity, Barrett’s Esophagus, and Esophageal Adenocarcinoma....Pages 133-145
Inflammation, Obesity, and Colon Cancer....Pages 147-180
Obesity, Inflammation, and Breast Cancer....Pages 181-217
Obesity, Inflammation, Nonalcoholic Fatty Liver Disease, and Hepatocellular Carcinoma....Pages 219-234
Obesity, Inflammation, and Prostate Cancer....Pages 235-256
Pharmacologic Interventions with NSAIDs....Pages 257-303
Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspective....Pages 305-339
Natural Products as Anti-inflammatory Agents....Pages 341-361
Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms....Pages 363-379
Vascular Targeting of Adipose Tissue....Pages 381-400
Anti-inflammatory Effects of Exercise....Pages 401-424
Back Matter....Pages 425-433
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