Ebook: Animal Models of Neurological Disease, I: Neurodegenerative Diseases

to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neu- psychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further research using animals is necessary and why animal models of psychi- ric and neurologic disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out.

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The use of animal models continues to be the most reliable way of studying pathophysiologic mechanisms as well as treatments for neurological disorders. In two companion volumes, Animal Models of Neurological Disease highlights new information and techniques available in this rapidly growing area.

This volume of Neuromethods focuses on commonly studied neurodegenerative diseases, highlighting the similarities and differences between the human condition and that obtained using animal models. Chapters are contributed by experts in the field and cover a variety of topics, including: the ethics of using animal models • Alzheimer's disease • Huntington's disease • Parkinson's disease • Lesch-Nyhan disease • genetic and nongenetic demyelinating diseases • cerebellar ataxias • rodent and primate models • surgical lesions • neurotoxins.

Boulton, Baker, and Butterworth's important new treatise on Animal Models of Neurological Disease is an outstanding guide for all researchers striving for a better understanding of neurological disease.

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The use of animal models continues to be the most reliable way of studying pathophysiologic mechanisms as well as treatments for neurological disorders. In two companion volumes, Animal Models of Neurological Disease highlights new information and techniques available in this rapidly growing area.

This volume of Neuromethods focuses on commonly studied neurodegenerative diseases, highlighting the similarities and differences between the human condition and that obtained using animal models. Chapters are contributed by experts in the field and cover a variety of topics, including: the ethics of using animal models • Alzheimer's disease • Huntington's disease • Parkinson's disease • Lesch-Nyhan disease • genetic and nongenetic demyelinating diseases • cerebellar ataxias • rodent and primate models • surgical lesions • neurotoxins.

Boulton, Baker, and Butterworth's important new treatise on Animal Models of Neurological Disease is an outstanding guide for all researchers striving for a better understanding of neurological disease.
Content:
Front Matter....Pages i-xvi
Back Matter....Pages 1-28
....Pages 29-63