Ebook: Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to Analysis and Interpretation

An essential, up-to-date guide to the design of studies and selection of the correct QoL instruments for observational studies and clinical trials. Quality of Life (QoL) outcomes or Person/Patient Reported Outcome Measures (PROMs) are now frequently being used in randomised controlled trials (RCTs) and observational studies. This book provides a practical guide to the design, analysis and interpretation of studies that use such outcomes. QoL outcomes tend to generate data with discrete, bounded and skewed distributions. Many investigators are concerned about the appropriateness of using standa. Read more... Measuring quality of life -- Choosing a quality of life measure for your study -- Design and sample size issues : how many subjects do I need for my study? -- Reliability and method comparison studies for quality of life measurements -- Summarizing, tabulating, and graphically displaying quality of life outcomes -- Cross-sectional analysis of quality of life outcomes -- Randomized controlled trials -- Exploring and modelling longitudinal quality of life data -- Advanced methods for analysing quality of life outcomes -- Economic evaluations -- Meta-analysis -- Practical issues