Ebook: Lead-Seeking Approaches

Christopher A. Lipinski: Overview of Hit to Lead: The Medicinal Chemist’s Role from HTS Retest to Lead Optimization Hand Off

Jeff W. Paslay • John E. Morin • Richard K. Harrison: High Throughput Screening in the Twenty - First Century

Jack Andrew Bikker • Lakshmi S.Narasimhan: Lead Discovery Using Virtual Screening

Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug Design

Kevin D. Freeman-Cook • Daniel W. Kung: Hit Triage – Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery

John W. Ellingboe • Adam M. Gilbert: Lead Identification

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This book contains topics that include: Overview of Hit to Lead: The Medicinal Chemist's Role from HTS Retest to Lead Optimization Hand Off (Christopher A. Lipinski); High Throughput Screening in the 21st Century (Jeff W. Paslay, John E. Morin, and Richard K. Harrison); Lead Discovery Using Virtual Screening (Jack Andrew Bikker and Lakshmi S. Narasimhan); NMR Spectroscopy in Fragment Based Drug Design (Maurizio Pellecchia); Hit Triage - Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery (Kevin D. Freeman-Cook and Daniel W. Kung); and Lead Identification (John W. Ellingboe and Adam M. Gilbert).