Ebook: Mathematical Modeling of Evolution: Volume 2 Fitness Landscape, Red Queen, Evolutionary Enigmas, and Applications to Virology

This two-volume work focuses on the mathematical aspects of Darwinian evolution starting from the basic model of stochastic evolution of a single isolated locus in the presence of mutation to the multi–locus models of sexual and asexual populations. Volume 2 discusses the inference of fi tness landscape from DNA sequence data, discovery of the evolutionary roles of enygmatic traits, co-evolution of adversarial species, and various applications to virus evolution.

• Applications to real-life problems for HIV, influenza, and polio virus.
• Inference of fitness landscape from genomic data, against the noisy background of linkage.
• The evolutionary puzzles of HIV latency and progression to AIDS.