Ebook: Organozinc Derivatives and Transition Metal Catalysts: Formation of C-C Bonds by Cross-coupling
Author: Janine Cossy (editor)
- Year: 2023
- Publisher: De Gruyter
- Language: English
- epub
Organozinc reagents are less reactive than Grignard reagents but they are much more chemoselective. Since the Negishi cross-coupling reaction developed by Ei-ichi Negishi, who was awarded the Nobel Price in chemistry in 2010, a number of cross-coupling reactions involving organozinc derivatives and transition metal catalysts (Pd, Ni, Fe, Co, Cu, …) has been tuned up to form C-C bonds. This book on "Organozinc derivatives and transition metal catalysts" has been written by experts in the field and is a complement to the book entitled "Grignard reagents and transition metal catalysts" (a De Gruyter book, edited by J. Cossy).
Grignard reagents or organozinc reagents, that is the question? From a given substrate, what is the best organometallic reagent and the best transition metal to form a C-C bond by using a cross-coupling reaction? The solution might be found in these two books.
- Organozinc reagents are used in cross-coupling reactions and have better chemoselectivity and functional group tolerance than Grignard reagents.
- Catalysis of organozinc reagents using various metals for C-C bond formation is discussed.