Ebook: BLyS Ligands and Receptors

The BLyS/BAFF family of cytokines and receptors has captured and held the attention of B cell biologists during the last decade. Discovery of the two ligands and three receptors comprising this family has yielded a watershed of insights; fostering fresh paradigms in our views about the differentiation, selection, and homeostatic control of virtually all B cell subsets. Moreover, because these processes are intimately tied to the mechanistic underpinnings of immune tolerance and activation, increased understanding of these activities promises translational progress in autoimmunity, neoplasia, and transplantation.

This volume will center on the BLyS(BAFF) family of ligands and receptors. It will be divided into sections based on topics covering both basic and translational/clinical aspects of this molecular family's biology. It will focus heavily the BLyS family's role in the differentiation, selection, and regulation of primary and antigen-experienced B cells. Additional sections will cover clinical aspects of this family, including its association with autoimmunity and neoplasia, current thinking about the mechanistic basis for these associations, and the potential of BLyS family members as therapeutic targets. In addition, how BLyS family members play roles in other cell types may be included.