Ebook: Pharmacogenetics of breast cancer: towards the individualization of therapy

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become rout.;Preface -- Acknowledgments -- Contents -- Contributors -- 1 Pharmacogenetics of Breast Cancer: Toward the Individualization of Therapy -- 2 Pharmacology, Pharmacogenetics, and Pharmacoepidemiology: Three P's of Individualized Therapy -- 3 Role of Genetic Variability in Breast Cancer Treatment Outcomes -- 4 The Role of Epigenetics in Breast Cancer: Implications for Diagnosis, Prognosis, and Treatment -- 5 Comparative Genomic Hybridization and Copy Number Abnormalities in Breast Cancer -- 6 Gene Expression Profiling as an Emerging Diagnostic Tool to Personalize Chemotherapy Selection for Early Stage Breast Cancer -- 7 Gene Expression-Based Predictors of Prognosis and Response to Chemotherapy in Breast Cancer -- 8 Utilization of Genomic Signatures for Personalized Treatment of Breast Cancer -- 9 Personalized Medicine by the Use of Microarray Gene Expression Profiling -- 10 Predictive Markers for Targeted Breast Cancer Treatment -- 11 Circulating Tumor Cells in Individualizing Breast Cancer Therapy -- 12 Individualization of Endocrine Therapy in Breast Cancer -- 13 TAILORx: Rationale for the Study Design -- 14 Taking Prognostic Signatures to the Clinic -- 15 Tissue is the Issue -- 16 Acquisition and Preservation of Tissue for Microarray Analysis -- 17 Tapping into the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Gold Mine for Individualization of Breast Cancer Treatment -- 18 Breast Cancer Stem Cells and Their Niche: Lethal Seeds in Lethal Soil -- 19 Molecular Imaging in Individualized Cancer Management -- 20 Cancer Nanotechnology for Molecular Profiling and Individualized Therapy -- Index.