Ebook: Physicochemical and biomimetic properties in drug discovery: chromatographic techniques for lead optimization
Author: Valkó Klára
- Tags: Drug development--Statistical methods, MEDICAL--Pharmacology, Clinical trials--Statistical methods, Pharmaceutical biotechnology, Chromatographic analysis, Electronic books, Drug development -- Statistical methods, Clinical trials -- Statistical methods, MEDICAL -- Pharmacology
- Year: 2014
- Publisher: Wiley
- City: Hoboken;New Jersey
- Language: English
- epub
Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measure.;Cover; Title Page; Copyright; Preface; Chapter 1: The Drug Discovery Process; Summary; Question for Review; References; Chapter 2: Drug-Likeness and Physicochemical Property Space of known Drugs; Summary; Questions for Review; References; Chapter 3: Basic Pharmacokinetic Properties; Absorption; Plasma Protein Binding; Distribution; Volume of Distribution; Unbound Volume of Distribution; Half-Life; Metabolism and Clearance; Free Drug Hypothesis; Summary; Questions for Review; References; Chapter 4: Principles and Methods of Chromatography for the Application of Property Measurements.
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