Ebook: Viral Genome Replication

Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.

Viruses are responsible for a variety of human, animal, and plant diseases and now represent potential agents of terror. Academic, government, and corporate laboratories have devoted years of effort to the development of strategies to prevent or treat viral infections. Central to the multiplication strategy of all viruses is the process of genome replication. Enzymes critical to this step of the lifecycle have proven to be tractable targets for the development of antiviral agents. Furthermore, genome replication is essential for virus spread and is the main target for the development of antiviral agents. By combining studies of both RNA and DNA viruses - and more - into a single volume, the editors have created a mechanism for cross-talk between the fields that will produce synergy and could lead to more rapid discovery of approaches to treat viral infections.