Ebook: Molecular Mass Distribution Measurement by Mass Spectrometry. NIST Recommended Practice Guide

National Institute of Standards and Technology (NIST), Polymers Division, Materials Science and Engineering Laboratory, National Institute of Standards and Technology. Special Publication 960-21 —
April 2010. — 40 p.
This NIST Recommended Practice Guide presents a method that uses mass spectrometry to make a quantitative determination of the molecular mass distribution of narrow polydispersity synthetic molecular materials. The main obstacle for converting an oligomer-resolved mass spectrum (MS) into a valid molecular mass distribution (MMD) is the systematic uncertainty in the ion intensity axis of the mass spectrum. This guide demonstrates how to make gravimetric mixtures of analytes having the same general chemistry but differing in molecular mass distribution to 1) ascertain if mass bias is present for a given set of measurement conditions, 2) create a calibration curve to properly convert the MS to a valid MMD, and 3) determine systematic uncertainties for the calibration curve when certain specific conditions are met.The Molecular Mass Distribution
Mass Spectrometry Overview
The Metrology behind Molecular Mass Distribution Measurement by Mass Spectrometry
Step by Step Procedure for Quantitative Molecular Mass Distribution Measurement
Full mathematical theory for distinguishable/non-overlapping mixtures
Computer code to obtain estimate of Q/k0 from experimental data
Documentary standards
References