Ebook: Protein-Protein Interactions in Drug Discovery

Wiley, 2013. — 330 p.Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.Contents
List of Contributors
Preface
A Personal Foreword
Protein–Protein Interactions: An Overview
Prediction of Intra- and Interspecies Protein–Protein Interactions Facilitating Systems Biology Studies
Modulators of Protein–Protein Interactions: Importance of Three-Dimensionality
A Leap into the Chemical Space of Protein–Protein Interaction Inhibitors
Interactive Technologies for Leveraging the Known Chemistry of Anchor Residues to Disrupt Protein Interactions
SH3 Domains as Drug Targets
p53/MDM2 Antagonists: Towards Nongenotoxic Anticancer Treatments
Inhibition of LFA-1/ICAM Interaction for the Treatment of Autoimmune Diseases
The PIF Pocket of AGC Kinases: A Target Site for Allosteric Modulators and Protein–Protein Interaction Inhibitors
Retosiban and Epelsiban: Potent and Selective Orally Available Oxytocin Antagonists
Peptidic Inhibitors of Protein–Protein Interactions for Cell Adhesion Receptors: RGD Peptides and Beyond
Replace Strategy for Generating Non-ATP-Competitive Inhibitors of Cell Cycle Protein Kinases
Index