Ebook: Mass Spectrometry for Drug Discovery and Drug Development

Wiley, 2013. — 465 p.Facilitates the discovery and development of new, effective therapeutics
With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics.
Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers:
HPLC–high-resolution mass spectrometry for quantitative assays
Mass spectrometry for siRNA
Quantitative analysis of peptides
Mass spectrometry analysis of biological drugs
Applications that support medicinal chemistry investigations
Mass spectrometry imaging and profiling
Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field.
Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.Contents
Contributors
Preface
Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development
Utility of High-Resolution Mass Spectrometry for New Drug Discovery Applications
Quantitative Mass Spectrometry Considerations in a Regulated Environment
Mass Spectrometry for Quantitative In Vitro ADME Assays
Metabolite Identifi cation Using Mass Spectrometry in Drug Development
MS Analysis of Biological Drugs, Proteins, and Peptides
Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics
Liquid Extraction Surface Analysis (LESA): A New Mass Spectrometry-Based Technique for Ambient Surface Profiling
MS Applications in Support of Medicinal Chemistry Sciences
Imaging Mass Spectrometry of Proteins and
Imaging Mass Spectrometry for Drugs and Metabolites
Screening Reactive Metabolites: Role of Liquid Chromatography–High-Resolution Mass Spectrometry in Combination with Intelligent Data Mining Tools
Mass Spectrometry of
Mass Spectrometry for Metabolomics
Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High-Resolution Full Scan?
Index