Ebook: Fundamental Aspects of DNA Replication

InTech. 2011. 318 p.DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed. We hope that readers will find this book interesting, helpful and inspiring.ContentsAssembly and Regulation of the Pre-Replication Complex: Increasing Complexity in Sight of Diversified Function and Regulation
Regulation of DNA Replication Origin Licensing
Addressing the Enigma of MCM8 in DNA Replication
Regulation of MCM7 DNA Replication Licensing Activity
Regulation of Minichromosome Maintenance (MCM) Helicase in Response to Replication Stress
Cell Cycle Control of DNA Replication by Phosphorylation and Dephosphorylation of Replication-Initiation Proteins in Budding Yeast
Cdc6 Knockdown Renders p16INK4a Re-Activation, Leading to Senescence Human Breast Carcinoma Cells
Visualize Dynamics of Chromosome Structure Formation and DNA Repair/Recombination Coupled With DNA Replication: Tight Coupled Role of DNA Replication in Chromosome Compaction and DNA Recombination
Sequence-Directed DNA Curvature in Replication Origins Segments
Initiation of DNA Replication from Closed Circular DNA
Function of DNA Polymerase б in a Replication Fork and its Putative Roles in Genomic Stability and Eukaryotic Evolution
Quality Control of DNA Polymerase α
Mechanisms and Controls of DNA Replication in Bacteria
Propagating Epigenetic States During DNA Replication
Epigenetic Modifications: Genetic Basis of Environmental Stress Response
Relations Between Replication and Transcription