Ebook: Advances in Lactoferrin Research

Following the two meetings on Lactoferrin Structure and Function that were held in Honolulu, Hawaii, in 1993 and 1995, the Third International Conference on Lactoferrin Structure and Function was held in Le Touquet, France, and has successfully reinforced and diversified the previously created bridges between biochemists, clinicians, and companies. In fact, scientists, physicians, and people of industry from different domains have brought a wealth of recent information concerning biochemistry and technical advances in the identification of lactoferrin-derived compounds as well as cell biology, molecular biol­ ogy, pathology, and medical applications of lactoferrin and lactoferrin-derived com­ pounds. We were so delighted with the rapid growth of knowledge concerning many biologi­ cal and immunological functions of lactoferrins and the relationships between their struc­ ture and function, we wanted to share our pleasure with the readers interested in this field. The present book. which represents a review of some of the most exciting contributions, is intended to reflect the status of our knowledge and transmit our hopes for the future devel­ opment of in vivo applications of natural and recombinant lactoferrins. We would like to express our gratitude to the sponsors who contributed to the or­ ganization of the meeting in such a pleasant place and allowed the participation of several young researchers. We would also like to thank all the participants who have answered with enthusiasm our invitation and to every one of the Laboratoire de Chimie Biologique for the constant and efficient help.

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Three-Dimensional Structure of Lactoferrin: Implications for Function, Including Comparisons with Transferrin; E.N. Baker, et al. Structures of Buffalo and Mare Lactoferrins: Similarities, Differences, and Flexibility; A.K. Sharma, et al. Direct Detection and Quantitative Determination of Bovine Lactoferricin and Lactoferrin Fragments in Human Gastric Contents by Affinity Mass Spectrometry; H. Kuwata, etal. Analysis of Bovine Lactoferrin in Whey Using Capillary Electrophoresis (CE) and Micellar Electrokinetic Chromatography (MEKC); P. Riechel, et al. Structural and Immunochemical Studies on Bovine Lactoferrin Fragments; K. Shimazaki, et al. Role of the First N-Terminal Basic Cluster of Human Lactoferrin (R²R³R⁴R⁵) in the Interactions with the Jurkat Human Lymphoblastic T-Cells; D. Legrand, et al. Glycation Ligand Binding Motif in Lactoferrin: Implications in Diabetic Infection; Y.M. Li. Mouse Lactoferrin Gene: Promoter-Specific Regulation by EGF and cDNA Cloning of the EGF-Response-Element Binding Protein; C. Teng, et al. Cloning of Human Genomic Lactoferrin Sequence and Expression in the Mammary Glands of Transgenic Animals; S.J. Kim,et al. 33 Additional Articles. Index.