Ebook: Acute Renal Failure in the Critically Ill
Author: L. C. Racusen K. Trpkov K. Solez (auth.) Dr. med. Rinaldo Bellomo Dr. med. Claudio Ronco (eds.)
- Tags: Intensive / Critical Care Medicine, Anesthesiology
- Series: Update in Intensive Care and Emergency Medicine 20
- Year: 1995
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
Over the last 10 years the syndrome of severe acute renal failure has progressively changed in its epidemiology. It is now most frequently seen in critically ill patients, typically in the context of sepsis and multiorgan failure. This epidemiologic change has meant that intensive care physicians and nephrologists must now work in close cooperation at all times and must take many com plex issues of prevention, pathogenesis, and management into account that they did not previously have to tackle. Simultaneously, the last 10 years have seen the development of major technical and conceptual changes in the field of renal replacement therapy. There are now previously unavailable therapeutic options that provide physicians with a flexible and rapidly evolving armamentarium. The nutrition of these patients, previously limited by the par tial efficacy of renal replacement therapies, has also become more aggressive and more in tune with the needs of critically ill patients. Increased understanding of the pathogenesis of the multi organ failure syndrome has focused on the role of many soluble "mediators of injury" (cytokines, leukotrienes, prostanoids etc.). These molecules are likely to participate in the pathogenesis of acute renal failure. Their generation and disposal is also affected by different techniques of artificial renal support.
This book is a comprehensive "state-of-the-art" review of current knowledge in a growing area of intensive care and nephrology. It addresses the pathology and pathophysiology of acute renal failure in the critically ill and reviews in detail all known mechanisms of renal injury in these patients. The approach to prevention from renal injury and the physiology of renal recovery are also discussed. The book deals with a number of practical clinical issues from rhabdomyolysis to drug-induced renal failure, from heparorenal syndrome to nutrition, and from pediatric issues to drug use and dosage in these patients. Finally it focuses on all the issues related to hemodialysis and hemofiltration and discusses the pros and cons of different forms of renal replacement.