Ebook: C-Myc in B-Cell Neoplasia: 14th Workshop on Mechanisms in B-Cell Neoplasia
- Tags: Immunology, Cancer Research, Internal Medicine
- Series: Current Topics in Microbiology and Immunology 224
- Year: 1997
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
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The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.
The workshop "Mechanisms in B-Cell Neoplasia" focused on c-myc. The deregulation of c-myc transcription by retroviral insertion, chromosome translocation or gene amplification is a consistent oncogenic "mutation" in many forms of B-cell neoplasia. C-myc, like several other genes involved in neoplasia (e.g. ras, p53), is implicated in multiple aspects of cellular life. No single defined action has yet been established for myc. Research is currently concentrated on defining the important functions, and assigning these to various differentiation lineages. This book presents some perspectives on this complex problem.